Provigil vs Nuvigil: Mode of Action, Cost and Availability, Side Effects

If you’re working the night shift and struggle to stay awake, or if you suffer from daytime drowsiness due to any sleep disorder then you’ll be surprised to know that there are medicines that can make you feel extra alert.

In such cases, Provigil and Nuvigil are considered to be the best options. Provigil (generic modafinil) and Nuvigil are basically non-stimulant medications that are used to increase wakefulness for the people suffering from sleep apnea or shift work sleep disorder —but what will that mean? how do they work? And is one on top of the other?

What is Provigil?

Modafinil, sold under the name Provigil among others, is a medication to treat narcolepsy, hypersomnia, shift work disorder, or preventative apnea.

What is Nuvigil?

The active ingredient in Nuvigil is termed Armodafinil. It consists of solely the enantiomer of the racemic modafinil. It was approved by the U.S. The Food and Drug Administration in 2007.

What are the ingredients of Provigil and Nuvigil

As mentioned above Provigil contains the active ingredient referred to as ‘Modafinil’ that is a racemic compound. Nuvigil is the R-enantiomer of racemic modafinil—this sounds difficult, however, it simply means it’s a rather completely different chemical structure than Provigil and modafinil.

Nuvigil tablets can contain up to 250 mg of armodafinil and a few inactive ingredients like croscarmellose sodium, lactose monohydrate, magnesium stearate, etc.

How do they work?

Nuvigil (Armodafinil) and Provigil (Modafinil) boost brain activity to stimulate brain areas that are concerned in wakefulness. These medications will facilitate treat hypersomnia, obstructive sleep apnea (OSA), and shift work disorder (SWD).

Most possible, Provigil (modafinil) and Nuvigil enhance Intropin sign (meaning they release dopamine, a neurochemical than will promote wakefulness).

Both Provigil and Nuvigil increase the discharge of monoamines, specifically the catecholamines monoamine neurotransmitter from the conjugation terminals.

In terms of chemical composition, armodafinil is an Associate in Nursing compound of modafinil. Sometimes it’s possible that enantiomers of medication bind otherwise to receptors within the body and so have completely different effects. However, within the case of modafinil (Provigil) and armodafinil (Nuvigil), each medication has similar effects on the body.

In addition, Provigil could also be prescribed to treat attention mood disorders, depersonalization disorder, cognitive enhancement, fatigue, cocaine addiction, post-chemotherapy, cognitive impairment, fatigue, drug addiction, weight loss, as a doping agent and in military and enforcement.

Cost and availability

Provigil has many brands and trade names, whereas Nuvigil is generally more expensive and fewer brands. But if you want to get them online then you can visit our website and buy them at the best price.

Side effects

The common side effects of Provigil include back pain, headache, nausea, nervousness, stuffy nose, diarrhea, anxiety, dizziness, dyspepsia, and trouble sleeping. The more serious effects embody rash, a hypersensitive reaction involving the liver or blood cells, hives, mouth sores, blistering or peeling skin, swelling of the face, lips, eyes, tongue, legs or throat, bother swallowing or respiration, fever, shortness of breath, yellowing of the skin or dark urine.

The common side effects of Nuvigil are headache, nausea, dizziness, bother sleeping while the serious side effects are similar to the use of Provigil.

Comparison Chart:

Parameter Provigil Nuvigil
Active Ingredient Modafinil Armodafinil
Mode of Administration Oral Oral
Duration of effect 16 hours average 18 hours average
Onset of effects Up to 2 hours About 4 hours
Side effects More Lesser
Wakefulness Shorter Lasts longer

Cost

Less

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Modafinil for Gamers

What is Modafinil?

Modafinil is categorized as a eugeroic, which is a “wakefulness-promoting agent.” In more recent times, it has been known as a nootropic.

Modafinil – The Ultimate Smart Drug?

In reality, being an adult can be downright exhausting! We have demanding jobs. We have families. There are bills to cover. Stress. Traffic. There just never seems to be enough time in the day or energy to get ahead.

This brings us to the trending subject of so-called “smart drugs” — specifically, Modafinil. Who uses Modafinil? Actually many of us! Like Poker players, truck drivers, fitness professionals, Wall Street traders and especially pro-gamers. Do you know some of the professional players have long used items to increase their attentional span, stay awake longer, and increase their response time? Much like using cheat codes in games, gamers use Modafinil to enhance their abilities in tight or long matches.

Things you need to know about Modafinil

  • It’s not a stimulant: Modafinil acts as a stimulant, but it is actually a eugeroic agent. As classical stimulants do, it will not make you jittery or speedy. Modafinil also doesn’t have withdrawal or a crash.

  • It’s not addictive: In fact, modafinil can help people kick dependence.

  • It has few to no side effects: Modafinil is very safe. In fact, it was approved by the FDA.

  • It works really well: Have you ever seen the movie Limitless with Bradley Cooper? It’s predicated on modafinil. It provides superhuman mental processing, with few to no downsides to you.

How can Modafinil help gamers?

  1. Added Player Motivation
    All strenuous or demanding sports activities need exceptional amounts of inspiration. Thus, their inspired opponents can hardly do better than any demoralized gamer having a feeling of positivity. As such, taking a normal Modafinil dose about an hour-or-so before a gambling or gaming showdown could be a benefit.
  1. Gives Extra Aggressiveness
    Besides the dire need to figure out specific points-winning internet matches goes, anyone managing puzzles that are competitive must be able to act with a degree of deftly unforgiving swiftness. Incidentally, the average e-game is comprised in a considerably time-sensitive manner that apportions ones who do exactly the same with stunning rapidity but additional marks for participants who pull genius masterstrokes off.
  1. Greater Gaming Focus
    All Playstation varieties generally attempt to market the player’s capability to handle correlated elements in a uniquely predetermined fashion. Sitting in an e-games room, you will hear a few switching clicks and shrieks. This is the point where a closely focused contestant on Modafinil showcases the entire difference! The nootropics-empowered player will probably be always yelping a string of yelps, even though their goofing competitions keep mouthing one miscalculation after another.
  2. Memorization
    Another feature of a video gaming pro is the unerring capacity to remember important hacks and cheats, elemental arrangements and, possibly, a couple of determinants that are varying throughout plots. In especially tough variations — maybe top-level alternatives for advanced players that usually — you will have to recall details that are awfully critical. To successfully navigate across hundreds or thousands of complicated traps and baits, the embattled player must have a robust memory and of course, Modafinil will provide that.

Where Do You Buy Modafinil?

So now as you know, Modafinil functions as a magical pill which may make you more effective, effective, effective, and capable. You’d likely ask, “Where do I get me some of them?” This comes as no surprise. Who doesn’t want (and urgently need) a boost in brainpower (in tablet form, not)?

Modafinil is being bought by men and women online from labs in India, China, Mexico, Canada, and other countries. You can buy this from our website (whichever is applicable) at a reasonable price.

Modafinil and its uses

Modafinil is an oral drug that is used for improving wakefulness in people with excessive sleepiness. It does so by promoting wakefulness by stimulating the brain.

Sleepiness and lack of concentration are very widespread among students, gamers, stock traders, poker players, shift work employees, and more. In all cases, attention span and mental clarity creating impacts successful performances. Modafinil has been the secret behind many successes and is more recently becoming available to the average person. Modafinil has a secondary effect of steading the mood, lowering appetite, and increasing the feeling of endurance as well as reducing spontaneous decisions.

To put it differently, certain chemical components in this extraordinary nootropic product appear to definitely positively promote the consumer’s critical thinking and problem-solving capability.

Modafinil will boost your,

  • Memory
  • Endurance
  • Attention span
  • Fight sleep exhaustion
  • Flat out alter how our brains operate

In a fantastical sense, such as in how in which the miracle pill at the movie ‘Limitless’ lets Bradley Cooper’s personality to attain glory and riches. Modafinil is grease for one’s cognitive tools – a synaptic lubricant that normally healthy men and women are taking to function at optimum levels of clarity, endurance, and attention.

Uses

1. Cognitive Enhancer

Modafinil is a powerful cognitive enhancer, particularly among people that are sleep deprived or that have a lower IQ. It’s apparent that the way of assessing cognitive functioning efficiently is a place that requires an excellent deal more study, as acknowledged by nearly all the studies contained. The other facets of cognitive augmentation are subjective and reliant upon a private standpoint.

2. Sets – Off Wall Street Traders and poker players

More recently, it’s brought traders who do not just require a pick-me-up to acquire through a deadline; they will need to be on with no break, for weeks, even years at a time.

One can experience a level of concentration which you’d never imagined. The senses sort of shift to the visual, and basically it is very easy to stay visually focused with fewer distractions making it perfect for poker players and stock traders alike.

3. Boosts Gamers

One of the key features of a successful video gaming is the unerring ability to easily recall significant hacks and cheats, elemental arrangements, a lot of constants, and, possibly, a few varying determinants throughout diverse plots. In particularly tough variations – maybe top-level alternatives for advanced players who usually have to recall awfully crucial details inside a split-second. To successfully navigate around thousands or hundreds of complicated traps and baits, the normally embattled participant has to have a very robust memory. This all can be assisted by Modafinil.

Aside from the dire necessity to figure out specific points-winning online matches goes, anybody managing competitive puzzles also have to have the ability to behave with a level of deftly unforgiving swiftness. Incidentally, the ordinary e-game is comprised in a considerably time-sensitive manner that apportions additional marks for participants that not just pull off actual genius masterstrokes but ones who do exactly the exact same with stunning rapidity.

Apparently, all strenuous or demanding sports actions need exceptional amounts of inspiration. Therefore, taking a normal Modafinil dose about an hour-or-so before a gambling showdown could be a fairly tremendous benefit. Looking at different web testimonials outweigh the assorted advantages of this fantastic cognitive enhancer, you’ll certainly chance upon several grateful punters that have fruitfully employed it to the exact same end.

4. For Tech Wizards

Modafinil is popular among silicon valley tech wizards because it is a hardcore cognitive enhancer and a quintessential smart drug. Programmers are creating thousands of lines of code quickly and efficiently with the assistance of modafinil.

Conclusion

The non-medical uses of Modafinil — frequently dubbed a smart drug medication — to increase concentration or memory is referred to as pharmacological cognitive augmentation (PCE) has shown proven capabilities to improve one’s life and work.

Doctors Prescribe Modafinil

Modafinil-Blog-2

Doctors prescribe modafinil, sold under the brand name Provigil, to improve wakefulness in adults who are experiencing excessive sleepiness as a result of obstructive sleep apnea, shift work sleep disorder, or narcolepsy.
The Food and Drug Administration (FDA)

approved modafinil for the treatment of narcolepsy in 1998, and the agency approved its use for shift work sleep disorder and obstructive sleep apnea/hypopnea in 2003.

Researchers are not sure exactly how modafinil promotes wakefulness. One theory is that it may increase dopamine levels in the brain by inhibiting reuptake of dopamine, a neurotransmitter that moderates the way chemical signals move from one nerve cell to another.

Provigil is made by Cephalon, Inc. in two strengths, 100 mg and 200 mg. Various manufacturers, including Mylan Pharmaceuticals, Teva Pharmaceutical Industries, and Par Pharmaceutical Companies make the generic form. (Teva’s version of modafinil is actually brand-name Provigil that has been repackaged and sold as a generic.)

Cephalon Inc., which is now owned by Teva, won a court case that resulted in the dismissal of claims that it conspired with the makers of generics to delay cheaper versions of Provigil.

Modafinil enhances short-term memory allowing users to stay awake for long periods of time. It is sometimes used for performance enhancement by military pilots and soldiers during combat situations, and some now call it a “super drug”. Its off-label uses have contributed to an ongoing debate on how far to push the human body through the use of drugs.

In This Section:

  1. What Are the Key Things I Need to Know About Modafinil (Provigil)?
  2. Is There Anything Special I Should Discuss with My Doctor Before Taking Modafinil (Provigil)?

What Are the Key Things I Need to Know About Modafinil (Provigil)?
Modafinil is a federally controlled substance and should be used only as directed. Store it in a safe place to prevent misuse and abuse. It is against the law to sell or give modafinil to another person.

Modafinil (Provigil) Coupons & Prices
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The drug is not approved for use in children for any medical condition, and it’s unknown whether it’s safe or works in children under the age of 17.
For those who have obstructive sleep apnea, modafinil is used in conjunction with other medical treatments. It will not cure this or other sleep disorders, but it can help the sleepiness created by these conditions. It may not stop all your sleepiness, however, and it’s not a substitute for getting proper rest.
Modafinil can lead to serious side effects, including a serious rash or an allergic reaction affecting your liver or blood cells. These side effects may be life threatening and may require hospital treatment. You should stop taking the drug right away and call your doctor if you develop a skin rash, hives, sores in your mouth, blisters, peeling, or yellowing of your skin or eyes, trouble swallowing or breathing, dark urine or fever.

Don’t take modafinil if you are allergic to armodafinil (Nuvigil), lactose monohydrate, microcrystalline cellulose, pregelatinized starch, croscarmellose sodium, povidone and magnesium stearate.

Is There Anything Special I Should Discuss with My Doctor Before Taking Modafinil (Provigil)?
It’s important for people to talk to their doctors about all their health conditions before starting this medication, such as whether they have a history of mental health problems, including psychosis. Make sure your doctor is aware of any heart problems or if you have had a heart attack, have high blood pressure, liver or kidney illness, a history of drug or alcohol abuse or addiction, or if you are pregnant, planning to become pregnant or are breastfeeding. It is unknown whether the drug will pass into breast milk.

Be sure to tell the doctor about any and all medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements. In addition, if you are using hormonal birth control, you could have a higher chance of getting pregnant while on this medication, and one month after stopping it.

For those who do get pregnant while taking the medication, there is a registry available that collects and provides information about the safety of the drug. You can access the information by enrolling in the registry by calling 1-866-404-4106 or logging onto www.PROVIGILpregnancyregistry.com.
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Modafinil Side Effects
What Are the Most Common and Serious Side Effects of Modafinil (Provigil)?
Not all side effects need medical attention and may go away during treatment as your body adjusts to the medicine. Your doctor may also be able to help you prevent or reduce some of them.

The more common side effects range from anxiety and nausea to headache and nervousness.

The more common side effects include:
-Anxiety
-Headache
-Nausea
-Nervousness
People should also be on the lookout for a number of other side effects, which are not as common. Among them: back pain, a reduction in appetite, belching, diarrhea or having problems making a bowel movement.

In addition, other people may experience dryness of the skin or mouth, flushing or redness of the skin, feeling like they are constantly moving, have heartburn/indigestion, vomiting and muscle stiffness.
Less common side effects of Provigil include:
-Elevated blood pressure
-Somnolence
-Insomnia
-Sores, ulcers, or white spots on the lips or inside the mouth
-Stuffy/runny nose
-Swelling
-Tingling, burning, or prickling sensations in the skin
-Back pain
-Belching
-Decrease in appetite
-Diarrhea
-Difficulty having a bowel movement
-Dryness of the mouth
-Dryness of the skin
-Feeling of constant movement of self or surroundings
-Flushing or redness of the skin
-Heartburn and indigestion
-Muscle stiffness
-Vomiting
Stop taking the medication and call your doctor and/or get emergency help if you get any of the following serious side effects:
-Chest pain
-Palpitations
-Trouble breathing
-Fever
-Sore throat
-Headache
-Blistering, peeling, and red skin rash
-Severe tingling, numbness, pain, muscle weakness
-Easy bruising or bleeding
-White patches or sores inside your mouth or on your lips
-Depression
-Feeling anxious
-Sensing things that are not really there (hallucinations)
-Increase in activity (mania)
-Thoughts of suicide
-Aggression or other mental problems

Modafinil Interactions
In This Section:
1) Do Other Drugs Affect the Way Modafinil (Provigil) Works?
Should I Avoid Any Food, Drink or Activity While Taking Modafinil (Provigil)?
2) Do Other Drugs Affect the Way Modafinil (Provigil) Works?
Before starting modafinil, it’s important to inform your doctor about any and all medications you’re taking, including prescription, over-the-counter, vitamins and herbal products.
Many drugs may interact with modafinil, such as Propranolol or Inderal, Cyclosporine/ Neoral, Sandimmune, Gengraf; Rifampin/Rifadin, Rimactane, Rifater; sedatives like diazepam/Valium, midazolam/Versed or triazolam/Halcion as well as antifungal medications like itraconazole/Sporanox or ketoconazole/Nizoral.

Other drugs which may interact include:
-Carbamazepine (Carbatrol, Tegretol), phenytoin (Dilantin), or phenobarbital(Luminal, Solfoton)
-Amitriptyline (Elavil, -Etrafon), doxepin (Sinequan), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), and others
-Isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate)
-Cyclosporine (Neoral, Sandimmune, Gengraf)
-Propranolol (Inderal)
-Rifampin (Rifadin, Rimactane, Rifater)
-A sedative such as diazepam (Valium), midazolam (Versed), or triazolam (Halcion)
-Antifungal medications such as itraconazole (Sporanox) or ketoconazole (Nizoral)
-Seizure medication such as carbamazepine (Carbatrol, Tegretol), phenytoin (Dilantin), or phenobarbital (Luminal, Solfoton)
-Antidepressants such as amitriptyline (Elavil, Etrafon), doxepin (Sinequan), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), and others
-A MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate)
Should I Avoid Any Food, Drink or Activity While Taking Modafinil (Provigil)?
Modafinil affects the central nervous system so your thinking and reactions may be impaired.
Don’t drive a car or engage in other activities that require you to be alert.
Avoid drinking alcohol since it is unknown how this will affect you.
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Modafinil Dosage
In This Section:
-What Are the Typical Dosages for Modafinil (Provigil)?
-What Happens If I Take Too Much and Overdose??
-What Happens if I Miss a Dose or Don’t Take It As Prescribed??

What Are the Typical Dosages for Modafinil (Provigil)?
Modafinil comes in two strengths, 100 mg and 200 mg. It is usually taken in the morning to prevent daytime sleepiness or one hour before the start of a work shift.
If you are using the medication to treat obstructive sleep apnea, you may also be given a continuous positive airway pressure (CPAP) machine. The air pump is connected to a mask that blows pressurized air into your nose while you sleep, helping to keep your airways open to prevent obstruction.
Remember, the medication is not intended to take the place of getting proper sleep.

What Happens If I Take Too Much and Overdose?
If you feel you have taken too much modafinil or may have overdosed, seek emergency medical attention or call the Poison Helpline at 1-800-222-1222.

If you feel excited or agitated, confused, have trouble sleeping, experience nausea or diarrhea, these may be symptoms of overdose.

What Happens if I Miss a Dose or Don’t Take It As Prescribed?

It’s important to discuss how to handle a missed dose with your doctor. Don’t take extra medicine to make up for the missed dose.

If you miss a dose of modafinil, you should take it as soon as you remember. However, don’t take the medication unless you plan to be awake for several hours.

If it is close to your normal bedtime, you might want to skip the missed dose.

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What is Modafinil?

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Modafinil (Brand name: Provigil) is a wakefulness-promoting prescription drug that reduces the extreme sleepiness that accompanies sleep disorders including narcolepsy, obstructive sleep apnea, and shift work disorder (SWD).

It is sometimes used off-label to treat symptoms of ADHD in adults 18 years of age and older. This use is not approved by the FDA, but some research has shown improvement in ADHD symptoms when compared to a placebo. According to the FDA, modafinil is a federally controlled substance (C-IV) because it can be abused or lead to dependence. The safety and effectiveness for children has not been established.

Armodafanil (Nuvigil) is a drug similar to modafinil that could potentially have similar effects, but its impact on ADHD in adults has not yet been studied.

How to Use Modafinil
Before starting or refilling a modafinil prescription, read the medication guide included with your pills, as it may be updated with new information.

This guide should not replace a conversation with your doctor, who has a holistic view of your medical history, other diagnoses, and other prescriptions. If you have questions, ask your doctor or pharmacist before you begin taking the medication.

Dosage for Modafinil
As with all medications, follow your modafinil prescription instructions exactly. If a patient experiences upset stomach as a side effect, this medication can be taken with food.

Tablets are available in 100mg and 200mg dosages.
The recommended dosage is 200mg, taken orally, once daily in the morning (or just prior to beginning work for people with SWD). A reduced dose is recommended for elderly patients and patients with severe hepatic impairment.

Do not drink alcohol while taking this medication, as the use of modafinil with alcohol has not been studied.

Side Effects Associated with Modafinil
The most common side effects of modafinil are as follows: headache, back pain, nausea, nervousness, stuffy nose, diarrhea, feeling anxious, trouble sleeping, dizziness, and upset stomach.

Other serious side effects include: a serious rash or allergic reaction including Stevens-Johnson Syndrome; rapid swelling beneath the skin; new mental health problems such as depression, anxiety, aggression, hallucinations, and thoughts of suicide; and symptoms of a heart problem including chest pain, abnormal heartbeat, and trouble breathing. In rare cases, modafinil can create a multi-organ hypersensitivity reaction, which can be life-threatening. Stop taking modafinil and seek medical attention immediately if you experience any of these serious side effects.

Taking modafinil may impair your ability to drive, operate machinery, or perform other potentially dangerous tasks. If side effects are bothersome, or do not go away, talk to your doctor. Most people taking this medication do not experience any of these side effects.

Report to your doctor any heart-related problems or a family history of heart or blood pressure problems. Patients with structural cardiac abnormalities and other serious heart problems have experienced cardiac arrest while taking modafinil. Stimulants, like modafinil, can increase blood pressure and heart rate. Physicians should monitor these vital signs closely during treatment. Call your doctor immediately if you experience warning signs such as chest pain, shortness of breath, or fainting while taking modafinil.

Also disclose to your physician all mental health issues including any family history of psychosis, depression, or mania. Modafinil may create new or exacerbate existing mania, delusions, hallucinations, suicidal ideation, and aggression. Call your doctor immediately if you experience new or worsening mental health symptoms including depression or mania.

Elderly or debilitated patients with impaired hepatic or renal function should use caution and be observed closely when taking modafinil.

Stimulants like modafinil have a low potential for abuse and addiction. It is a “Schedule IV drug,” a designation that the Drug Enforcement Agency uses for drugs with a low potential for abuse. Other Schedule IV drugs include Xanax, Klonopin, and Valium. People with a history of drug abuse should use caution when using this medication. Taking the medication exactly as prescribed can reduce potential for abuse.
The above is not a complete list of potential side effects. If you notice any health changes not listed above, discuss them with your doctor or pharmacist.

Precautions Associated with Modafinil
Store modafinil in a secure place out of the reach of children, and at room temperature. Do not share your modafinil prescription with anyone, even another person with ADHD. Sharing prescription medication is illegal, and can cause harm.

You should not take modafinil if you have any of the following conditions: allergy or hypersensitivity to modafinil, armodafinil or any of the ingredients in modafinil medications.

If you’re thinking of becoming pregnant, discuss the use of Modafinil with your doctor. Animal studies indicate a potential risk of fetal harm. It is not known if modafinil is passed through breastmilk, so it is recommended that mothers do not nurse while taking it.

The safety of Modafinil for children under age 17 has not been established.

Interactions Associated with Modafinil
Before taking Modafinil, discuss all other active prescription medications with your doctor.

Use caution when taking modafinil concurrently with MAOIs. Certain illegal drugs such as methamphetamine and MDMA/ecstasy can interact with modafinil.

Modafinil can decrease the effectiveness of hormonal birth control including pills, shots, patches, vaginal rings, and intrauterine devices (IUDs) – while taking modafinil, and for one month after stopping modafinil. Talk to your doctor about the birth control choices that can reduce the risk of becoming pregnant while taking modafinil.

Modafinil can increase the speed at which certain medications are processed by your body, which could decrease their effectiveness.  Examples of medications that could be affected include: cyclosporine.

Modafinil can increase concentrations of certain medications in the body, including omeprazole, phenytoin and diazepam.
Caffeine can increase the side effects of modafinil.

Share a list of all vitamin or herbal supplements, and prescription and non-prescription medications you take with the pharmacist when you fill your prescription, and let all doctors and physicians know you are taking modafinil before having any surgery or laboratory tests. The above is not a complete list of all possible drug interactions.

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