Provigil vs Nuvigil: Mode of Action, Cost and Availability, Side Effects

If you’re working the night shift and struggle to stay awake, or if you suffer from daytime drowsiness due to any sleep disorder then you’ll be surprised to know that there are medicines that can make you feel extra alert.

In such cases, Provigil and Nuvigil are considered to be the best options. Provigil (generic modafinil) and Nuvigil are basically non-stimulant medications that are used to increase wakefulness for the people suffering from sleep apnea or shift work sleep disorder —but what will that mean? how do they work? And is one on top of the other?

What is Provigil?

Modafinil, sold under the name Provigil among others, is a medication to treat narcolepsy, hypersomnia, shift work disorder, or preventative apnea.

What is Nuvigil?

The active ingredient in Nuvigil is termed Armodafinil. It consists of solely the enantiomer of the racemic modafinil. It was approved by the U.S. The Food and Drug Administration in 2007.

What are the ingredients of Provigil and Nuvigil

As mentioned above Provigil contains the active ingredient referred to as ‘Modafinil’ that is a racemic compound. Nuvigil is the R-enantiomer of racemic modafinil—this sounds difficult, however, it simply means it’s a rather completely different chemical structure than Provigil and modafinil.

Nuvigil tablets can contain up to 250 mg of armodafinil and a few inactive ingredients like croscarmellose sodium, lactose monohydrate, magnesium stearate, etc.

How do they work?

Nuvigil (Armodafinil) and Provigil (Modafinil) boost brain activity to stimulate brain areas that are concerned in wakefulness. These medications will facilitate treat hypersomnia, obstructive sleep apnea (OSA), and shift work disorder (SWD).

Most possible, Provigil (modafinil) and Nuvigil enhance Intropin sign (meaning they release dopamine, a neurochemical than will promote wakefulness).

Both Provigil and Nuvigil increase the discharge of monoamines, specifically the catecholamines monoamine neurotransmitter from the conjugation terminals.

In terms of chemical composition, armodafinil is an Associate in Nursing compound of modafinil. Sometimes it’s possible that enantiomers of medication bind otherwise to receptors within the body and so have completely different effects. However, within the case of modafinil (Provigil) and armodafinil (Nuvigil), each medication has similar effects on the body.

In addition, Provigil could also be prescribed to treat attention mood disorders, depersonalization disorder, cognitive enhancement, fatigue, cocaine addiction, post-chemotherapy, cognitive impairment, fatigue, drug addiction, weight loss, as a doping agent and in military and enforcement.

Cost and availability

Provigil has many brands and trade names, whereas Nuvigil is generally more expensive and fewer brands. But if you want to get them online then you can visit our website and buy them at the best price.

Side effects

The common side effects of Provigil include back pain, headache, nausea, nervousness, stuffy nose, diarrhea, anxiety, dizziness, dyspepsia, and trouble sleeping. The more serious effects embody rash, a hypersensitive reaction involving the liver or blood cells, hives, mouth sores, blistering or peeling skin, swelling of the face, lips, eyes, tongue, legs or throat, bother swallowing or respiration, fever, shortness of breath, yellowing of the skin or dark urine.

The common side effects of Nuvigil are headache, nausea, dizziness, bother sleeping while the serious side effects are similar to the use of Provigil.

Comparison Chart:

Parameter Provigil Nuvigil
Active Ingredient Modafinil Armodafinil
Mode of Administration Oral Oral
Duration of effect 16 hours average 18 hours average
Onset of effects Up to 2 hours About 4 hours
Side effects More Lesser
Wakefulness Shorter Lasts longer





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